الفهرس | Only 14 pages are availabe for public view |
Abstract Hepatotoxicity implies chemical-driven liver damage. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Chemicals that cause liver injury are called hepatotoxins. In the present study, the protective effects of Honey and Bee venom either independently or in combination against hepatoxicity in male albino rats were investigated. The administration of honey and/or BV showed a significant hepatoprotective potential effect against LPS+CCl4 induced hepatoxicity in rats. The statistical analysis obtained in the current study showed positive percentages of improvement in liver function enzymes to some extent.The administration of honey and BV to the LPS/CCl4 group resulted in the enhancement in the oxidative stress biomarker, LPx, suggesting their antioxidant role. The administration of honey and BV individually or together showed the highest percentages of improvement in the hematological, kidney parameters and histopathological changes in the liver as a result of LPS/CCl4 exposure. |