الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present as noninflammatory lesions, inflammatory lesions, or a mixture of both, affecting mostly the face but also the back and chest. Adipokines were demonstrated to be associated with multiple cutaneous diseases. Leptin is mainly produced by the adipocytes that stem from the obese gene. In addition, it was reported that, secretion of leptin is a response to increased lipid uptake, thus, it might be regarded as a link between improper diet and the development of inflammatory acne. In addition, adiponectin was reported to have an anti-inflammatory effect on endothelial cells by inhibiting the following: nuclear factor κB activation. Moreover, the adiponectin/leptin ratio has been suggested as a marker of adipose tissue dysfunction. This emerging biomarker correlates negatively with BMI, thus, obesity was reported to be associated with a generalized change in the levels of circulating adipokines. The aim of the current study was to estimate serum leptin and adiponectin in both obese and non-obese patients with acne vulgaris and evaluate A /L rates as a biomarker of insulin resistance & hence their role in pathogenesis of acne vulgaris in correlation with body weight and disease severity. Our study was a prospective case control study conducted on a total of 60 patients with acne vulgaris subdivided in to 30 non-obese patients and 30 obese patients and matched age and sex 40 healthy controls. Both groups (acne vulgaris verso controls) demonstrated insignificant differences concerning age, sex, BMI and obesity. • The mean duration was 3.93 ± 2.85 and the mean Global acne score was 23.48 ± 11.02 among cases with acne vulgaris. • In terms of disease severity (GAGS), the majority of cases were mild (43.3%) and moderate (33.3%), while nine cases were severe (15%) and only five cases were very severe (8.3%). • Cases with acne vulgaris demonstrated significant increase in serum leptin level as well as significant decrease in serum adiponectin level compared to controls. • No significant correlation was reported between both serum leptin and adiponectin levels and disease severity. • Obese cases were associated with a significant increase in leptin level compared to non-obese ones. • No significant difference was recorded among among obese and non-obese ones as regards adiponectin level. • There was significant increase in leptin and significant decrease in adiponectin among obese cases compared to non-obese cases. • Leptin could be used as reliable predictor in terms of the differentiation between cases of acne vulgaris and controls with high sensitivity, specificity and accuracy. • Adiponectin could be used as reliable predictor in terms of the differentiation between cases of acne vulgaris and controls with high sensitivity, specificity and accuracy. • Global Acne Grading System was demonstrated to be correlated significantly with both serum leptin and adiponectin among acne vulgaris patients. • Cases with acne vulgaris were reported to have lower adiponectin /leptin ratio compared to controls.