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العنوان
Evaluation of Efficacy of Botulinum Toxin (A) Injection and Topical Minoxidil Alone Versus their Combination in the Treatment of Male Androgenetic Alopecia /
المؤلف
Elshebiny, Nehal Mohammad Hassan.
هيئة الاعداد
باحث / نهال محمد حسن الشبينى
مشرف / عبير عبد الحكم هديب
مشرف / ايمان عادل حسبى
مشرف / غاده فوزى رزق حسن
الموضوع
Dermatology.
تاريخ النشر
2021.
عدد الصفحات
p 160. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب التناسلي
تاريخ الإجازة
22/9/2021
مكان الإجازة
جامعة طنطا - كلية الطب - الجلديه والتناسليه
الفهرس
Only 14 pages are availabe for public view

from 200

from 200

Abstract

Summary Androgenetic alopecia is the most common patterned hair loss in males that develops in genetically susceptible patients under the effect of multiple endogenous and exogenous factors. It is characterized by progressive miniaturization of terminal hair and its transformation to vellus hair at the vertex and temporal areas. FDA-approved treatment includes topical minoxidil 5%, systemic Finasteride, and LLLT. Minoxidil which was originally used as an anti-hypertensive drug was found to increase hair growth. It is used topically in a concentration of 2% and 5% twice daily and causes vasodilatation by its opening effect over the potassium channels thus prevents the shortening of the anagen phase and reduces the telogen follicles. Botulinum toxin is a neurotoxin produced by Clostridium botulinum bacterium and exerts its muscle relaxant effect via preventing the release of acetylcholine at the neuromuscular junction. It’s used in various medical aspects as strabismus which is the first disease to be treated with BoNT. Also, it has a wide range of applications in dermatology, as treating wrinkles and rhytides, in addition to its role in controlling hyperhidrosis and many other dermatological diseases. It has been found that there is vascular insufficiency at the bald areas, in addition to the tightness of scalp muscles which leads to a decrease of blood in the intramuscular blood vessels. Intramuscular injections of BoNT cause scalp muscle relaxation thus increase the blood supply. The present study aimed to evaluate and compare the efficacy of botulinum toxin (A) injection only and topical minoxidil alone and their combination in treating male AGA. It was conducted at the Outpatient Clinic