الفهرس 
HBV infectionOnly 14 pages are availabe for public view
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Abstract
Background and aim: Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel serum diagnostic marker for liver fibrosis in various liver diseases. We aimed to evaluate its role in assessment of liver fibrosis in chronic hepatitis B infection (CHB) with reference to liver stiffness measurement (LSM) by transient elastography (Fibroscan).
Design and Methods: A case control study. 50 CHB patients with LSM by transient elastography technology and retrievable serum samples and 20 normal volunteers as a control group were recruited.
Results: 50 CHB patients (M: F = 30:20; mean age 43years ± 10.58) and 20 normal control volunteers (M: F = 12:8; mean age 37years ± 14.5) were recruited. The mean M2BPGi values for control group, F0-F1, F2, F3 and F4 progressively increased with more advanced stages of liver fibrosis: 0.282, 0.719, 1.322, 1.65 and 1.904 COI, respectively (p < 0.001). M2BPGi levels has significant positive correlation with liver stiffness (r = 0.911), with FIB-4 (r = 0.682) and with APRI (r = 0.536) (all p < 0.001). There was a statistically significant positive correlation between M2BPGi serum level and INR (r = 0.333, p = 0.018). And there was a statistically significant negative correlation between M2BPGi serum level and platelet count (r = -0.41, p = 0.003) and HBV DNA (r = -0.373, p = 0.008).There was a statistically significance between M2BPGi serum level and the history of varices (p = 0.023)
For diagnosing F2-F3, the AUROC of serum M2BPGi was 0.993 with the optimal cutoff value 1.02 COI with sensitivity and specificity 100% & 92.6% respectively.
For diagnosing F4, the AUROC of serum M2BPGi was 1 with the optimal cutoff value 1.71 COI with sensitivity and specificity 100% & 100% respectively.
Conclusions: WFA+-M2BP is an accurate serum indicator for assessing different stages of liver fibrosis. WFA+-M2BP provides a simple and reliable alternative or complementary method to liver biopsy and Fibroscan.