الفهرس 
Nonalcoholic Fatty Liver Disease
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Abstract
Background: As a result of the obesity pandemic, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. NAFLD is the hepatic manifestation of obesity and a precursor of and independent risk factor for type 2 diabetes
Aim of the Work: To assess the level of vascular cell adhesion molecule 1 (VCAM-1) as non-invasive diagnostic tools for diagnosis of NAFLD degree of fibrosis.
Patients and Methods: A Case-Control clinical study in the Internal medicine and hepatology outpatient clinic at Ain Shams University Hospital for 6-month on 60 persons that were included in this study divided into 2 groups: group A: 30 patient with NAFLD as a study group. group B: 30 healthy subjects as a control group.
Results: In the present study, the mean VCAM-1 was 2.392± 0.3 in NAFLD group, 9.893± 2.3 in NASH group and 1.983 ± 0.3 in control group with high statistical significant increase in NASH followed by NAFLD than in control group. Regarding to ROC curve, VCAM-1 had excellent Diagnostic performance with an AUC of 0.994. A best cut-off criterion of VCAM-1 > 7.7 ng/mL could discriminate between patients with NASH from control group with a sensitivity of 95% and specificity of 100% In our study, there was no significant correlation in between VCAM-1 and age, AST, ALT In the present study, the significant predictors of bad outcome in patients with NAFLD and NASH were higher VCAM-1 level, GGT and higher AST levels
Conclusion: The significant predictors of bad outcome in patients with NAFLD and NASH were higher VCAM-1 level, GGT and higher AST levels.