الفهرس 
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Abstract
Cancer chemotherapy includes several side effects such as nausea and vomiting. The oral route for administration of anti-emetic drugs is not the ideal choice especially for children; loss of administered drug can occur through vomiting before the oral dose exerts its effect. In addition, oral administration of some drugs can cause gastro-intestinal side effects. To avoid or reduce these effects, the transdermal route is a suitable alternative. The present thesis focused on the antiemetic drug Ondansetron hydrochloride (OSH) commonly prescribed orally in the treatment of chemotherapy-induced nausea and vomiting.
Specifically, the thesis focused on designing an affordable transdermal OSH formulation that can be prepared within the facilities available in a hospital compounding lab. Among the transdermal dosage forms, patches, films and in situ films, it was decided to focus on transdermal films that can be prepared by a simple casting process. Dose flexibility can be achieved through the film surface area. The formulation factors studies included the chemical form of the drug whether salt or unionized base, and the absence or presence and concentration of a permeation enhancer