الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 128 |  |  |
| | | from | 128 | | |
Abstract
Polycystic ovary syndrome (PCOS) is a metabolic syndrome, characterized by anovulation, hyperandrogenism and polycystic ovary, PCOS exists commonly among women at reproductive age and is the most frequent cause of anovulatory infertility in women and is often associated with menstrual irregularities. Thyroid dysfunction may also be associated with fertility problems, women with undiagnosed PCOS may often be referred to thyroid gland examination. Diseases causing hyperthyroidism or hypothyroidism can also induce menstrual disorders and fertility consequences. Thyroid disorders and polycystic ovary syndrome (PCOS) are two of the most common endocrine disorders in the general population. Although the etiopathogenesis of hypothyroidism and PCOS is completely different, these two entities have many features in common. An increase in ovarian volume and cystic changes in ovaries have been reported in primary hypothyroidism. In the other direction, it is increasingly realized that thyroid disorders are more common in women with PCOS as compared to the normal population. There are few data showing improved fertility outcomes in women with subclinical hypothyroidism treated with thyroid hormone. In observational studies of women with infertility and subclinical hypothyroidism, 44 to 84 percent of women treated with T4 successfully conceived during treatment. This cross sectional study was conducted at Mansoura University Hospital in the period between Jan. 2018 and Jan. 2020. The population of this study was 100 infertile patients in child bearing period diagnosed to have PCOS using Rotterdam criteria were enrolled in the study; 80 patients were euthyroid, 12 patients with subclinical hypothyroidism and 8 patients with hypothyroidism. Statistical analysis of our results showed prevalence of hypothyroidism among PCO patients was 8%, 12% with subclnical hypothyroidism and 80% were euthyroid. Statistical analysis of our results showed Mean ± SD age among the studied group was 29.07±5.35 ranged from 21 to 41 years. About one third of the studied group (35 patients) were less than 25 y. On the other hand Mean ± age in euthyrod patients was 28.38±4.58 compared to 26.33±2.74 and 40.00±1.07 in subclinical hypothyroidism and hypothyroid patients respectively with statistically significant difference. Statistical analysis of our results showed that mean ± SD BMI among the studied group was 30.43±4.99. About two thirds of the studied group were obese (65 patients) while one third (35 patients) were non obese On the other hand there was statistically significant relation between hypothyroidism and obesity as Mean BMI was higher in hyothyrodism cases 36.87±1.84 compared to 32.08±5.50 and 29.53±4.61 in subclinical hypothyroidism and euthyroid patients respectively. Statistical analysis of our results showed that mean ± SD duration of infertility among the studied group was 4.64±3.19 years ranged from 1.5 years to 13 years.[ two thirds of the studied group were suffering from primary infertility (68 patients) while one third (32 patients) were suffering from secondary infertility].On the other hand there was no statistically significant relation between hypothyroidism and type of infertility. but there was statistically significant relation between duration of infertility and hypothyroidism p value. On the other hand Statistical analysis of our results showed that no statistically significant difference was observed between hypothyroidism and FSH and LH levels.. Mean Testosterone level was significantly higher in hypothyroid and subclinical hypothyroid patients compared to euthyroid patients.aslo A significant relation was observed between hypothyroidism and anti TPO (p value 0.001). Median anti TPO (229 Iu/ml) was higher in hypothyroidism cases compared to (53.1 14.2 Iu/ml) in subclinical hypothyroidism and euthyroid patients respectively Also Significant correlation was observed between PCO and thyroid hormones. There was statistically significant negative correlation between T3 and Testosterone The same pattern was observed with Anti TPO Decreased T3 level was associated with increased Testosterone level and Anti TPO. In addition, statistically significant negative correlation was observed between T4 and Anti TPO, LH and BMI. Moreover, statistically significant positive correlation was observed between TSH and Anti TPO. The same positive correlation was observed with duration of infertility and BMI. Also, increased TSH level was associated with increased Anti TPO.