الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The present thesis comprises the following chapters:
Chapter I (Introduction):
An introductory part describing the chemistry of 4-thiazolidinones particularly rhodanine ring and different approaches for its reactions which included the modification of the ring.
Chapter II (Research Objectives):
The aim of this research is to synthesize structural analogues of repaglinide ® and epalreastat®. Our strategy is directed toward the design of a variety of ligands by attaching new moieties at C-5 of rhodanine ring of substituted 4-benzylidine derivatives and/or by varying the aniline substitution pattern related to aceyamide moiety in the hope of discovering potential ALR2 inhibitors with significant hypoglycemic activities.
Chapter III (Theoretical Discussion):
A theoretical discussion of synthetic pathways that have been followed to obtain final new compounds and their mechanisms, spectral data, biological results and molecular modeling.
Chapter IV (Experimental):
A number of new rhodanine derivatives and their analogues were synthesized. The potential inhibition of the synthesized compounds was tested on ALR2 using in vitro methodology. The hypoglycemic activity was tested on B-cell using in vivo methodology Docking study for the most active was carried out on the crystal structure of SUR1 membrane protein, ALR2 and ALR1.
Chapter V (Conclusion):
A summary of the present study, conclusions and the future work.
Chapter VI (References):
A list of references which were used and their arrangement according to their order in the thesis.