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Abstract Infected neonates with sepsis are a clinical case that need to quickly diagnosing as well as management. Biomarkers have a decisive role in disorder physiological process associated with sepsis, they can illustrate the extent risk of septicemia and can discriminate the source infection; if it is from bacteria, fungi or virus as well as from local or systemic sepsis. MicroRNAs (miRNA) are single-stranded non-coding RNAs.A lot of these microRNAs completely or partially were implicated in gene silencing; they’re additionally concerned in the transcriptional activation and co-activation of many genes. Furthermore, the misregulation of several miRNAs is linked to the development of certain diseases in humans and other organisms. As result to the scarcity of published researches which demonstrate the role of miRNAs in diagnosis of neonatal sepsis. So, we conducted this research to evaluate the role of miRNA 15b and miRNA 378a as diagnostic biomarkers for neonatal sepsis. |