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Abstract Cancer is a life-threatening disease, the World Health Organization (WHO) reported that 9.6 million people died from cancer in 2018. Breast cancer represents one third of cancer cases threatening the female population relative to males due to mammary lactate glands and their proliferation ability. Estrogen is the female sex hormone responsible for development and fertility of female organs. Phytoestrogens have a similar action to estrogens that can bind to estrogen receptors (ER) and activate them. Phytoestrogens include flavones, lignans, coumestans and triterpenes. Phytoestrogens have anticarcinogenic potential and they have also significant estrogenic properties. Inspired by the activity of triterpenes and polysaccharides isolated from the medicinal mushroom Ganoderma, we chose this genus for further investigation. The fruiting bodies of Ganoderma resinaceum were collected from living Ficus tree in Mansoura IV University Campus, Egypt and laboratory culturing of its mycelia was performed. |