الفهرس 
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Abstract
Asprosin is a newly discovered fasting induced protein hormone that promotes glucose production from the liver. It is the C-terminal cleavage product of profibrillin (encoded by Fibrillin-1 (FBN1)). Various tissues produce it across the body but the white adipose tissue seems to contribute to this production with the largest proportion. Asprosin is a gluconeogenic hormone that exerts its action by binding to the G protein receptor and activates PKA-cAMP axis to induce hepatic glucose production and release. Glucose is a powerful and potent negative regulator of asprosin as concluded from acute DROP in serum asprosin levels in mice after feeding. Amelioration of hyperinsulinemia and insulin resistance associated with obesity is a cardinal target for therapeutics.
Forty-mature male Wistar rats, weighing an average of 260±19.2 gm and aged 8 weeks were acclimatized for fourteen days in a laboratory before being placed at the animal house. Rats divided into four groups (10 rats each) as the following:
• group A; control group which was given a standard diet with an intraperitoneal injection I/P of saline (Control).
• group B; given a standard diet and injected I/P with oxytocin (Control + OX).
• group C; given high-fat high sugar diet (HFHSD), and injected I/P with saline (C1: Prediabetic, C2: Diabetic).
• group D; given HFHSD and injected I/P with oxytocin (D1: Prediabetic + OX, D2: Diabetic + OX).