الفهرس 
Idiopathic nephrotic syndromeOnly 14 pages are availabe for public view
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Abstract
Idiopathic nephrotic syndrome is the most common presentation of glomerular disease in children. The syndrome is characterized by the tetrad of massive proteinuria (proteinuria exceeding 40mg/m2/h or spot urinary protein creatinine ratio exceeding 2mg/mg), hypoalbuminemia 2,5g/dl), edema and hyperlipidemia (serum cholesterol 200 mg/dl). The main two histological subtypes of INS encountered in children are MCNS and FSGS. More than 90% of children with MCNS achieve remission with corticosteroid within the first 4 weeks and hence MCNS is identified as SSNS, in contrast the majority of patient with FSGS are resistant to corticosteroid therapy and hence FSGS is identified as SRNS. The prognosis of disease correlates closely with the patients’ response to steroids. Idiopathic MCN (SSNS) and FSGS (SRNS) require early differentiation in order to ensure prompt therapeutic intervention and better outcome. So several urinary or blood markers were studied which can predict renal pathology or steroid responsiveness without the need for invasive renal biopsy. The aim of this study was to evaluate urinary CD80 and Serum soluble urokinase-type plasminogen activator receptor (SuPAR) in patients with primary nephrotic syndrome and use them as noninvasive diagnostic biomarkers to differentiate the different clinical phenotypes of primary nephrotic syndrome.Sixty patients with INS aged from 1-18 years and 30 healthy children of matched age and sex serving as a control group were included in this study. The patients were subdivided according to corticosteroid therapy into 30,30 patients having SSNS and SRNS