الفهرس 
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Abstract
Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus (DM). Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the current understanding of this point of view remains controversial. The aim of this study was to detect any relation between vitamin D deficiency and increase risk of peripheral neuropathy in type 2 diabetes. The study included total number of 90 subjects; 60 cases with type 2 DM and will be divided into two groups; one with peripheral neuropathy, the other group without peripheral neuropathy and 30 healthy subjects as control. All the included cases were subjected to full history taking (history of current disease, past history and family history), clinical examination (general and neurological) and laboratory investigation including analysis of serum levels of (Complete blood count, Fasting blood glucose, Liver function test, Kidney function test, Glomerular filtration rate GFR, HbA1c, Cholesterol and triglyceride). Assessment of serum level of vitamin D was conducted in all the cases. All the included subjects were examined to assess the degree of presence or absence of retinopathy. The results of this study showed that. * This study showed that the mean age and sex distribution of the subjects included in the study didn’t reveal significant difference between the three groups. * The FBG level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with T2DM without peripheral neuropathy group and the control group. Also, The FBG level was statistically significantly higher in the T2DM without peripheral neuropathy group as compared with the control group. * The 2Hr-PPG level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with T2DM without peripheral neuropathy group and the control group. Also, the 2Hr-PPG level was statistically significantly higher in the T2DM without peripheral neuropathy group as compared with the control group. * The HbA1c level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with T2DM without peripheral neuropathy group and the control group. Also, the HbA1C level was statistically significantly higher in the T2DM without peripheral neuropathy group as compared with the control group. * The triglycerides level was statistically significantly higher in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * The HDL level was statistically significantly lower in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * ALT level was statistically significantly higher in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * AST level was statistically significantly higher in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * Urea level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with the control group. * The creatinine level was statistically significantly higher in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * The uric level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with the control group. The uric level was statistically significantly higher in the T2DM with peripheral neuropathy group as compared with the T2DM without peripheral neuropathy group. * CRP level was statistically significantly higher in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * The eGFR was statistically significantly lower in the T2DM with peripheral neuropathy group and as compared with the control group. * The mean SBP was statistically significantly higher in the T2DM with peripheral neuropathy group and T2DM without peripheral neuropathy group as compared with the control group. * There was highly statistically significant affection regarding nerve conduction velocity status (NCV) in the T2DM with peripheral neuropathy group as compared with the T2DM without peripheral neuropathy and control groups. * The serum level of vitamin D was statistically significantly higher in the control group as compared with the T2DM without peripheral neuropathy group and T2DM with peripheral neuropathy group and the level was statistically significantly higher in the T2DM without peripheral neuropathy group as compared with the T2DM with peripheral neuropathy group. * There was highly statistically significant increase in the percentage of cases with retinopathy in the group with T2DM with peripheral neuropathy group as compared with the T2DM without peripheral neuropathy group and control groups. By multivariate regression analysis, increased disease duration, high HbA1c, ACR, CRP, SBP and decreased vitamin D levels were shown to be independent risk predictors for diabetic peripheral neuropathy.