الفهرس 
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Abstract
Skeletal muscle injuries are frequently encountered in athletes and military personnel. Incomplete functional recovery of these injuries usually occurs due to fibrosis of the skeletal muscle. Recently, Platelet Rich Plasma (PRP) with oral administration of losartan (Los) antihypertensive drug were claimed to have a role in improving skeletal muscle healing, but still to be furtherly investigated.
Aim of the work: To assess the effect of PRP with or without Los on skeletal muscle healing after experimentally induced laceration in skeletal muscle of adult male albino rats.
Material and Methods: Ninety-five male albino rats were used in this study and were divided into five groups: group I: served as a control group and included 30 adult rats. group II (muscle laceration left for healing): 20 rats were subjected to muscle laceration injury. group III (PRP-treated group): 15 rats were subjected to muscle laceration injury then PRP was injected once directly at injury site. group IV (Los-treated group): 15 rats were subjected to muscle laceration injury followed by administration of oral Los starting from day three. group V (PRP and Los-treated group): 15 rats were subjected to muscle laceration injury, then they received both PRP and Los. Five rats from each group were sacrificed after one, two and four weeks. Muscle injury and healing were evaluated by light microscope, immunohistochemical and transmission electron microscopic examination.