الفهرس 
Parkinson’s disease (PD)Only 14 pages are availabe for public view
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Abstract
Background: Fatigue is generally defined as a sense of exhaustion for a defined period that is unexplained by drug effects, medical, or psychiatric disorders. In Parkinson’s disease (PD), fatigue is considered one of the most common and disabling non motor symptoms, which may manifest even during premotor stages of disease, and once present may often persist or even worsen over time. Aim of the study: is to study fatigue whether it’s primary or secondary in idiopathic Parkinson’s disease (PD) patients. Methods: A case control study was conducted on 50 patients with Parkinson’s disease attending involuntary movements outpatient clinic at Ain Shams University Hospitals and Ain Shams University Specialized Hospital and 50 control subjects of relatives or accompanying person of the patients. UPDRS scale, PD NMS questionnaire, Parkinson’s disease fatigue scale, Pittsburg sleep quality index, RBDS questionnaire, Restless legs syndrome scale, Beck depression scale and Parkinson’s anxiety scale were done for all cases. Results: This study showed significant correlation between fatigue scale result and scores of levodopa equivalent dose, UPDRS III, IV and sleep quality while there was no significant correlation between fatigue and other parameters including depression, anxiety, restless leg, sleep quality and REM sleep behavioral disorder. Conclusion: Fatigue is a major problem for approximately half the PD population and tends to develop early. There are few data regarding the relationship of fatigue to gender, age of onset of fatigue, onset of motor symptoms of PD, or its correlation with other medical or behavioral co morbidities aside from depression.