الفهرس 
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Abstract
The complications of wounds and their lack of healing is a problem that worries many population, especially those working in the field of surgery, so many scientists and researchers are in a continuous search for ways and treatments to speed up the healing process of wounds and shorten the stage of inflammation, which is one of the most important dynamic stages in the wound healing process. Several researchers have found that topical insulin has an active effect in accelerating wound healing.
Insulin is a peptide used to treat Type 1 diabetes and some cases with Type 2, has been reported to improve the recovery of acute and chronic wounds in diabetic patients. Insulin has special structure, which gives it distinctive properties such as its ability to form new blood vessels (angiogenesis effect) and has the ability to treat local inflammation, which greatly helps in the healing process of wounds.
Insulin also has many preparations on the market, varying between short-acting, medium-acting and long-acting.
The aim of our study is two fields; firstly to evaluate the effect of topical insulin on both diabetic and non-diabetic patients in Upper Egypt. The second aim is to compare between the effect of short acting insulin, as we used what represents it which is (Actrapid®) and the long acting insulin (Lantus®) which represented it, when they are used topically in the same dose.
We used the concentration 4 units (0.1ml) for each 10 cm2 from human soluble insulin whether short acting or long acting. We had measured the wounds area by disposable ruler and we had followed the rat of healing until complete healing has occurred.
The groups under study that were treated with topical insulin whether it was short acting or long acting insulin showed significant difference in the number of treatment days, UHT(day/cm2), PUSH scale score, and NRT scale scoring, where a decrease in all those parameters was noticed during the study.
In this study, we concluded that topical insulin has a positive effect on the speed of wound healing in diabetic and non-diabetic patients, but there is no clear difference between short-acting and long-acting insulin.