الفهرس 
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Abstract
• Male are more affected than Female as regards gastric adenocarcinoma. • Age ˃ 50 years is associated with increasedrisk of gastric adenocarcinoma. • Upper gastro endoscopy is more accurate than CT scan in diagnosis of gastric adenocarcinoma. • CT scan was used inTNM staging before surgery. • The antrumwas the most common site of gastric adenocarcinoma as diagnosed byupper GI endoscopy. • P-m TOR expression was positive 54.5%,AKT expression was positive in 72.7% and PI3K expression was positive in 36.4% of GC. • There was a statistically significant higher pAKT score and positive pAKT score in radiological regional lymph node metastatic than non-metastatic cases. In addition, Positive PI3K was higher in radiological regional lymph node metastatic than non-metastatic cases. • There is statistically significant correlation between PI3K score and presence of diabetes (PI3K score is lower in diabetic patients). • AKT score at a cutoff value of more than 3 is a statistically significant discriminator of regional radiological lymph node metastatic versus non-metastatic gastric adenocarcinoma (AUC=0.743 = good diagnostic accuracy) • The sensitivity and specificity of m TOR score in diagnosis of metastatic versus. non-metastatic gastric carcinoma was 56.5% and 80% respectively. • The sensitivity and specificity of AKT score in diagnosis of metastatic versus. non-metastatic gastric carcinoma was 87% and 60%respectively.