الفهرس 
English CoverOnly 14 pages are availabe for public view
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Abstract
The treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne. Treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes-resistant nature delineate the need for alternative therapies. Therefore, over the past decade, phototherapy has been introduced for the treatment of acne, such as pulsed dye lasers (PDLs) and photodynamic therapy (PDT).The aim of this study was to compare the safety and efficacy of PDL and methylene blue-mediated photodynamic therapy (MB-PDT) in two different vehicles for the treatment of mild to moderate acne. A split-face clinical trial including thirty patients presenting with mild to moderate acne were treated with 585 nm PDL on the right side of the face and MB-PDT with 665 nm diode laser on the left side was conducted. The photosensitizer MB was prepared in nanoemulgel formulation and Penetration enhancer vesicles (PEVs), the treatment was carried out for three sessions maximum at 2-weeks intervals.Results revealed that both PDL and MB-PDT were effective therapies in the treatment of acne, as manifested by the reduction of inflammatory and noninflammatory lesions throughout the treatment period. However, MB-PDT was proven more potent in the reduction of acne severity, and in terms of patients’ tolerance. Therefore, it can be concluded that MB in the nanoemulgel or PEVs form is a promising treatment approach for acne, and can be further experimented in the treatment of other dermatological diseases.