الفهرس 
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Abstract
Vitiligo is an acquired idiopathic depigmenting skin and
mucous membranes that are characterized by well-circumscribed,
depigmented macules, and patches that occur secondary to selective
destruction of melanocytes.
Vitiligo affects about 0.5% to 2% of the world’s population
without difference of race or sex. Pathogenesis of Vitiligo is
considered to be a multifactorial and polygenic disease caused by the
destruction of melanocytes.
S100B is a member of calcium-binding protein which is
expressed in melanocytes, astrocytes, oligodendrocytes, neural
progenitor cells, Schwann cells, kidney epithelial cells, adipocytes,
skeletal myofibers, Langerhans cells, and a subpopulation of
lymphocytes. It acts as a stimulator of cell proliferation, migration, an
inhibitor of apoptosis and differentiation.
This study aims to evaluate the correlation between serum level
of S100B and Vitiligo activity.
. The patients were selected from the outpatient clinic in
dermatology and STDs department in Faculty of Medicine, Menoufia
University in the period from December 2019 till March 2020.
Informed consents were obtained from parents of all participants. The
study was approved by the local ethics committee on research
involving human subjects, Faculty of Medicine, Menoufia
University.Our study is a case-control study that included 60 patients
with Vitiligo who were diagnosed with clinical evaluation and 30
healthy individuals as a control group. There were no