الفهرس 
EpidemiologyOnly 14 pages are availabe for public view
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Abstract
SUMMARY AND CONCLUSION Psoriasis is one of the common skin diseases world-wide, affecting approximately 2–4% of the population worldwide. It is a chronic, complex, systemic, immune-mediated inflammatory disease with an extensive emotional and psychosocial effect on patients. Although exact etiology of Ps is not fully understood, genetic and environmental factors along with immune system may contribute in the development of Ps. It presents clinically as sharply demarcated erythematous plaques with adherent silvery white scales. Plaque Ps is the most common clinical subtype. It can start at any age and affects both sexes equally. Abnormal epidermal differentiation, hyperproliferation, loss of granular cell layer, parakeratosis, inflammation and angiogenesis are common histopathological changes in Ps.
Phototherapy represents a mainstay treatment for Ps vulgaris. Ps lesions can be healed by the NB-UVB at a length of 311 nanometers, which has more impact than broadband ultraviolet as it has a long time of remission, low burning sensation and less carcinogenic. NB-UVB therapy is known to reverse several pathologic alterations in Ps as it decreases the number of epidermal T lymphocytes and dendritic cells during therapy. In addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy was found to target the IL-17 pathway. Caveolin is a major structural scaffold and regulatory component of the caveolae in the membranes. Three isoforms of Cav have been detected in mammals; Cav-1, Cav-2, and Cav-3. Caveolin-1 and Cav-2 are generally distributed in mechanically stressed cells, such as endothelial cells, fibroblasts, adipocytes and muscle cells. Caveolin -1 is involved in secretion of lamellar bodies, formation of junctions in epidermal keratinocytes and