الفهرس 
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Abstract
Summary
Epilepsy is one of the most important neurological diseases in children. AEDs greatly control it but their ADRs are challenging.
This study was designed to assess the prevalence of ADRs of AEDs in children with idiopathic epilepsy, this study was conducted on 51 children with epilepsy recruited from neurology outpatient clinic of the pediatric department in Beni-Suef University hospital.
All Patients subjected to the following:
• Medical history of the patient
• Full data on the pharmacotherapy.
• .Electroencephalogram (EEG).
• A- Laboratory investigations:
• CBC.
• Liver enzymes; ALT and AST & Albumin.
• Serum levels of calcium (Ca+2).
• Serum levels of Sodium (Na).
• For information which is not recorded in the medical case sheets, direct patient or patient relatives interviews will be conducted using a structured questionnaire.
• Clinical progress of the patient collected from the clinical progress notes, and follow up investigation results.
The results of the present study revealed the following:
• Out of the 51 patients, prevalence of patients who experienced ADRs was 43 (84.3%), while patients who experienced adverse DDIs were 19 (37.3%).
• The present study included a total of 25 female patients and 26 male patients. 72% of the females experienced ADRs while 96.2% of the males experienced ADRs indicating that that there were significant differences as regard the sex of patient as the prevalence of ADRs was significantly more than females.
• ADRs of AEDs affecting nearly almost systems and it was evident mainly on CBC, calcium level, Psychatric and behavioral, additionally affecting cognitive functions, GIT disturbances, liver enzymes and hair.
• Polytherapy of AEDs may result in additive DDIs so caution and monitoring is critical.
• The most common type of epilepsy among patients in the current study is GTC.
• There were no significant difference between the prevalence of ADRs and type of delivery, consanguinity and age of patients.
• ADRs had been occurred sometimes regardless dose, duration of treatment or the combination of drugs.