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Abstract Background: Ureteroscopy had been recognized as a major method for treating ureteric calculi. Although invasive, the development of smaller and more flexible ureteroscopes, and a new generation of various intracorporial lithotripters, has made this procedure safer and more effective. Placing a ureteric stent after ureteroscopy with stone extraction is done by some urologists routinely to prevent possible stenosis or to decrease secondary pain caused by mucosal oedema. Objective: To evaluate and compare the efficacy and safety of Tadalafil and Tamsulosin in reliving Double-J stent-related symptoms following uncomplicated ureteroscopic lithotripsy (URSL) and percutaneous nephrolithotomy (PCNL). Patients and Methods: The present study was a prospective randomized comparative study conducted on 80 patients (56 men and 24 women) with double-J stent inserted following uncomplicated ureteroscopic lithotripsy (URSL) and unilateral percutaneous nephrolithotomy (PCNL) in Ain Shams University Hospital and Sohag Educational hospital over a period of 1 year. Results: The study shows that Tadalafil is safe and effective in relieving DJ related symptoms. Tadalafil 5 mg once / day is as effective as Tamsulosin 0.4 mg once / day in relieving urinary symptom and body pain but more effective in relieving sexual symptoms and general health. Conclusion: The study shows that Tadalafil is safe and effective in relieving DJ related symptoms. Tadalafil 5 mg once / day is as effective as Tamsulosin 0.4 mg once / day in relieving urinary symptom and body pain but more effective in relieving sexual symptoms and general health. Therefore Tadalafil 5 mg once / day could be recommended as preferred drug in sexually active patients undergoing DJ stenting. |