الفهرس 
Anatomy and pathophysiology of the retinaOnly 14 pages are availabe for public view
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Abstract
ROP remains a leading cause of treatable childhood blindness throughout the world: both the developed countries and emerging economies. Currently, concerns have been raised about an emerging international ROP epidemic due to multiple factors including a boom of surviving premature neonates.
Timely screening of premature infants at risk is as important as early treatment in the management of ROP. Hence, appropriate screening guidelines and timely treatment protocols need to be followed and implemented in every neonatal unit by pediatricians and ophthalmologists to reduce the ROP-related blindness in the community.
We aimed to develop a screening tool for early postnatal prediction of ROP in preterm newborns based on risk factors within the first 48h of postnatal life.
This study was conducted on 200 neonates who was admitted in NICU department of Benha University Hospital and naser general Hospital. Preterm patients less than 35w gestational age and exposed to any risk factors, as antenatal and postnatal risk factors( chorioamnionitis, preeclampsia, placental infection, exposure to supplemental oxygen during the first few weeks after birth, the presence of patent ductus arteriosus, the use of surfactant ,transfusion, sepsis, postnatal weight gain and genetic factors were included to our study. Preterm patients with major congenital anomalies were excluded.
All neonates were subjected to full history taking and complete clinical examination. Complete blood count, CRP, Bleeding profile, Liver function, renal function, Torch screening. Fundus examination: by indirect ophthalmoscope, digital imaging of selected cases.
Our results relieved that:
• there was significant statistical increase ROP among patients with decreased BW and GA.
• There was no statistically significant difference between group 1 (ROP group) and group 2 (Non ROP group) as regards head circumference, gender and temperature within 1 hour On the other hand.
• there is significant statistical increase ROP among patients from mothers with chorioamnionitis and not recicvied antenatal steroids.There was no statistically significant difference between group 1 and group 2 as regards antenatal magnesium, maternal hypertension, and mode of delivery.
• there is significant statistical difference between means of two studied groups regarding sepsis.
• There was no statistically significant difference between group 1 and group 2 as regards RDS, O2 need during resuscitation.
• There was no statistically significant difference between group 1 and group 2 as regard Apgar score.
• There were statically significant between time of nicu admission and Rop.
• As we found in our study, when selecting 1.35 Kg cutoff point of birth weight as predictive value of getting ROP patients with birth weight less than 1.35 are more likely to have ROP, as 100% of them were diagnosed as actual ROP (sensitivity). The proportion of actual negatives that are correctly identified as negative (ROP) more than 1.35 Kg is 94.2% (specificity). Birth weight can separate well the tested group into those with and without ROP.
• As we found in our study, when selecting 33.5 weeks cutoff point gestational age at birth as predictive value of getting ROP patients with GA less than 33.5 are more likely to have ROP, as 100% of them were diagnosed as actual ROP (sensitivity). The proportion of actual negatives that are correctly identified as negative (ROP) more than 33.5 weeks is 82.2% (specificity). Gestational age can separate well the tested group into those with and without ROP.
• Multivariate logistic regression analysis for associated risk factors of ROP in the studied group, there was significant predictors of ROP of selected covariates according to Gestational age,Birth weight,sepsis,time of nicu admission.