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Abstract In the present study, we have evaluated effect of Zinc Oxide nanoparticles or Allopurinol on lead induced kidney injury in rat. This study was carried out on 60 male albino rats weighting 150gm used in this experiment. They are obtained from the animal house in faculty of veterinary medicine, Zagazig University. Animals are maintained in stainless steel cages in Biochemistry department under hygienic conditions. Animals received standard rat diet and water for 14 days before the experiment for adaptation. Rats were classified into 6 groups as following: The control group 10 rats were received saline orally for 2 months daily using rat oral tubing connected to insulin syringe. Second group was received zinc oxide nanoparticles (5 mg/kg) given orally to 10 rats / 2 months using rat oral tubing connected to insulin syringe. Third group was received Allopurinol (100mg/kg) given orally to 10 rats / 2 months using rat oral tubing connected to insulin syringe. Fourth group was received Lead Acetate (60mg/kg) given orally to 10 rats / 2 months using rat oral tubing connected to insulin syringe. Fifth group was received Zinc oxide nanoparticles and Lead Acetate given orally to 10 rats / 2 months using rat oral tubing connected to insulin syringe. Sixth group was received Allopurinol and Lead Acetate given orally to 10 rats / 2 months using rat oral tubing connected to insulin syringe. |