الفهرس 
I NSULIN R ESISTANCE AND P REDIABETESOnly 14 pages are availabe for public view
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Abstract
Background: One of the most important complications of obesity and prediabetes is nephropathy so it is very important to early detect nephropathy in these patients for better prognosis.
Objective: To evaluate the level of urinary nephrin as a marker of nephropathy in obese prediabetic patients.
Patients and Methods: This cross sectional observational study was conducted on 90 persons, their age ranged from 30 to70 years old from the outpatient clinic of Dar El-Shefa hospital between December 2019 till may 2020. The study was explained to all persons and, and an informed consent was obtained from them before starting the study. Subjects were be divided in to three groups, groupI (30 obese non pre diabetic patients), group II (30 obese pre diabetic patients) and group III (30 healthy control).
Results: Our results show that there is highly statistical significant difference between the three studied groups regarding nephrin being higher in group II (obese prediabetic patients) in which nephrin level is 675 – 1725 pg/ml followed by group I (obese non prediabetic patients) in which nephrin level is 170 – 930 pg/ml then group III (control group) in which nephrin level is 75 – 900 pg/ml and P value (< 0.001). 2HPP is the only independent factors that affect level of nephrin level.
Conclusion: This study shows that nephrin level in urine is increased in obese prediabetic patients which indicate early nephropathy, drawing attention to the possibility to use urinary nephrin as a marker of nephropathy in obese prediabetic patients, helping us for early detection of nephropathy, providing an opportunity for early intervention and prevention of complications.
Abbreviations: Body mass index (BMI), chronic kidney disease (CKD), Estimated glomerular filtration rate (eGFR), End-stage renal disease (ESRD), Normal glucose tolerance (NGT), Urinary tract infection (UTI), Waist to hip ratio (WHR).