الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most common cancer in women and the second most common cancer overall. Indeed, the possibility of in identification of specific biomarkers have added clinical practical possibility for the prognostic and therapeutic strategies. Aim of the Work: We aimed to assess IHC staining for Notch1 and β-catenin in relation to molecular subtypes of breast carcinoma from one side and their relation to different clinicopathological prognostic criteria and patient survival on the other side, to evaluate the role of Notch1 receptor and β-catenin in progression of breast tissue from DCIS to invasive breast cancer. Material and methods: The study included One hundred paraffin blocks from which 6 TMA blocks were constructed and stained with Notch1 and β-catenin IHC. The results were correlated with histopathological parameters and patient survival to identify different prognostic factors. Statistical analysis then was done later. Results: Notch1 overexpression associated with progression of breast tissue from DCIS to IDC. It was commonly seen in high grade tumors and mainly expressed in her2 enriched, triple negative tumors as well as associated with poor clinical prognosis. Abnormal β-catenin expression was significantly increased for both DCIS and IDC relative to benign breast tissue, so may have a definite role in breast carcinogenesis. It was mainly expressed in her2 enriched, triple negative tumors Also, it was an independent prognostic indicator for DFS and high cytoplasmic expression was associated with poor clinical outcome and worse prognosis. Conclusion: In the results of this study provided important evidence that Notch1 and β-catenin are players in breast tumorigenesis and progression. Thus, Inhibition of both could be used to reduce breast cancer progression. In addition, Notch1 and β-catenin can be defined as prognostic factors for survival, can predict the outcome of patients with invasive ductal breast carcinoma.