الفهرس 
Polycystic Ovary Syndrome (PCOSOnly 14 pages are availabe for public view
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Abstract
Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, characterized by hyperandrogenism, anovulation, and polycystic ovaries, which significantly increase risk of infertility. The mainstay treatment for infertility in PCOS patients is ovulation induction which may cause one of the most serious complication which is Ovarian hyper stimulation syndrome.
Objective: The aim of the current study was to compare conventional GnRH-antagonist protocol with and without LE in PCOS patients at high risk of ovarian hyperstimulation syndrome (OHSS).
Patients and methods: This was double blinded: A prospective randomized controlled study which was conducted in In Vitro Fertilization (IVF) unit, Ain Shams Maternity Hospitals on 44 women, during period from February 2020 to December 2020. The patients were randomly divided into 2 equal groups: group (A): Control group: consisted of PCOS women who received COS with conventional multiple-dose GnRH- antagonist protocol and placebo, and group (B): Study group: consisted of women with PCOS who received COS with a conventional antagonist protocol and LE.
Results: The results of the current study revealed that no statistical significant difference between studied groups as regard OHSS & low count before trigger. There was 7 patient (31.8%) developed OHSS in group A. While, there was 2 patients (9.1%) developed OHSS in group B before trigger. In group A, there were 5 patients (71.4%) of mild OHSS and 2 patients (28.8%) of moderate OHSS. In group B, there were 2 patients (100%) of mild OHSS. There was 3 patient (13.6%) of low count in group A and no patients of low count in group B. Also it was found that no statistical significant difference between studied groups as regard OHSS after trigger. There was 1 patient (4.5%) developed OHSS of moderate grade in group A while there were no patients developed OHSS in group B after trigger.
Conclusion: The current study concluded that the Addition of LH to conventional GnRH-antagonist protocol in PCOS patients which are at high risk of OHSS may be the same as using conventional GnRH-antagonist protocol only in prevention of OHSS in controlled ovarian stimulation (COS) during IVF.