الفهرس 
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Abstract
Vitiligo is an acquired skin depigmentation disorder affecting 0.5 - 1% of the world population. The disease may affect individuals of both sexes. It occurs when melanocytes die or unable to function and mostly characterized by loss of melanocytes .Despite much research, the etiology of vitiligo and melanocyte death is not clear. It is related to both genetic and non-genetic factors, but there are many theories concerning the cause such as the autoimmune, autocytotoxic and neural hypothesis.
Interferon-induced helicase 1 gene (IFIH1), also called melanoma differentiation- associated gene 5 (MDA-5), is a locus in the innate immunity viral RNA receptor gene region on chromosome (2q24.3( (Gene ID: 64135). The IFIH1 has been reported to be associated with several autoimmune diseases such as Type 1 diabetes mellitus, Graves’ disease, multiple sclerosis, psoriasis, and possibly lupus erythematosus. All missense variants of IFIH1, i.e. rs1990760, rs3747517, and rs35667974, showed association with vitiligo in the independent replication study and the former two showed associations in all three genome-wide association studies.
This work aimed to study the role of IFIH1 gene polymorphisms (rs1990760), (rs35667974), (rs587777447) in vitiligo susceptibility and protection. All patients were selected from Outpatient Clinic of Dermatology, Andrology & STDs, Menoufia University Hospital during the period from November 2019 to march 2021 .