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Abstract This experiment was carried out in the laboratory of the aquaculture department, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Egypt, from 22 December 2019 – 15 April 2020. This study aimed to evaluate the efficiency of Ulva fasciata methyl extract- supplemented diets to improve the growth performance and the immune response of Nile tilapia (O. niloticus) fries. To achieve these objectives, we used the following methodology: Fish (1.32±0.12 g) g were obtained from a private fish hatchery, Kafr El-Sheikh, Egypt, to the laboratory at Faculty of Fisheries and Aquatic Science, Kafr El-sheik University Four treatments were evaluated each treatment contain 45 fish in triplicate groups: U0, the control, fish receives a basal diet (control diet); U50, a basal diet with 50 mg kg-1 UFE; U100, a basal diet with 100 mg kg-1 UFE; U150, a basal diet with 150 mg kg-1. After acclimatization, experimental fish groups were established and fed on different doses of UFE for 90 successive days before being challenged. Blood and liver samples were taken before challenge for pre-challenge analyses such as growth-related genes expressions analyses, beside hemato-biochemical and immune- oxidative parameters analyses. Intestines samples were taken for intestinal morphometry analyses. |