الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
English summery
In this work, the synthesized graphene oxide nanoparticles, iron oxide nanoparticles, chitosan nanoparticles and this nanoparticle are used for the formation of the composite with the modified chitosan. As nano-carriers for anti-cancer drugs. The following thesis contains three main chapters followed by relevant references in addition to the English and Arabic summaries
Chapter (1): Introduction
The introduction consists of the knowledge and the basic of nanomaterials, the preparation methods in various fields. Also contains literature survey on the nanotechnology importance and its applications in modern life, as well as certain types of nanomaterials such magnetite, graphene oxide, and chitosan nanoparticles applications and its synthesis techniques.
Chapter (2): Material and method
This chapter includes the experimental part of this thesis. It has a complete description of chemicals, reagents and methods for the preparation chitosan nanoparticles using ionic gelation method and from shrimp and preparation magnetite nanoparticles using co-precipitation method using two alkalis and preparation graphene oxide nanoparticles using modified hummer method, and the compilation of the formerly synthesized nanoparticles with chitosan forming nanocomposites and also The prepared composite used as drug delivery for carboplatin drug. The factors affecting the loading and release the drug studied. This chapter has the description of the characterization tools for the synthesized materials (XRD, FT-IR, FE-SEM VSM and HR-TEM techniques).
Chapter (3): Results and discussion
This Chapter has the results of obtained data. It can be divided into two parts as the following:
Part I: characterization of the synthesized material
It presents the characterization of the prepared chitosan nanoparticles, magnetite nanoparticles, graphene oxide nanoparticles and their composites with modified chitosan as magnetite nanoparticles were prepared using co- precipitation method using two alkalis and the prepared magnetite nanoparticles were characterized by utilizing as XRD, FT-IR, FE-SEM HR- TEM, and VSM techniques .Graphene oxide were prepared with modified hummer method and characterized by utilizing as XRD, FT-IR. Chitosan nanoparticles were prepared using two method the first method using shrimps and second method using ionic gelation method and characterized by utilizing as XRD, FT-IR also nano composites of prepared with modified chitosan were characterized by utilizing as XRD, FT-IR as the crystallite sizes of samples were determined using XRD and TEM techniques and both techniques determine particle and crystalline size in the nano rang and FT-IR spectra of the prepared samples assigned to the formation of nano particles bands and FT-IR displays the masking the bands related to the structure after the formation of the composite with chitosan. VSM showed tm saturation magnetization of magnetite nanoparticles. TEM and SEM images described the appearance of cubic spinal shape of prepared magnetite nanoparticles.
Part II: application part
a) Loading of carboplatin anticancer drug on chitosan nanoparticles, magnetite chitosan nanoparticles, graphene oxide chitosan nanoparticles and magnetite graphene oxide chitosan nanoparticles and results showed that the drug loading capacity for them indicating high drug loading efficiency .
b) Release of carboplatin drug loaded on chitosan nanoparticles, magnetite chitosan nanoparticles, graphene oxide chitosan nanoparticles and magnetite graphene oxide chitosan nanoparticles this part shows that carboplatin could be continuously released the best result of drug release always in low pH with all different drug carriers.
C) Evaluation of cytotoxicity and cell surviving against MCF-7 cells line. Results of that study showed that carboplatin drug loaded CS-Fe3O4-GO the best cell surviving against cancer cells and CS-Fe3O4-GO composite and carboplatin showed low cell surviving against cancer cells.
D) Evaluation of cytotoxicity and cell surviving against HepG-2 cells line. Results of that study showed that carboplatin drug loaded CS-Fe3O4-GO the best cell surviving against cancer cells and CS-Fe3O4-GO composite and carboplatin showed low cell surviving against cancer cells