الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Aging is the process through which young individuals, who are often healthy and don’t require medical care, become older adults, whose diminishing physiological fitness leads to an increase in the risk of illness and mortality
Mild cognitive impairment (MCI) is four times common than dementia in terms of prevalence. The decline and disturbance of cognitive, little impairment of complex skills, ability to conduct ordinary daily functions, and the absence of dementia are all features of MCI. Memory loss and cognitive deterioration occur at a faster rate than would be predicted for a person’s age and educational level in typical MCI, although daily activities are unaffected.
MCI affects between 12 and 18 percent of persons over the age of 60 and has a higher probability of progressing to dementia in about 50% of cases.
Chronic low-grade inflammation is a feature of biological ageing. This long-term process has been termed ”inflamm-aging,” and it is a major risk factor for disease and mortality in the elderly. Oxidative stress, impaired mitochondrial function, immune system dysregulation, hormonal alterations, glycation, epigenetic modifications and telomere shortening are some of the most prominent theories of inflamm-aging.
Inflamm-aging performs an important role in the onset and progression of diseases related to age such as mild cognitive impairment and Alzheimer’s disease.
Interleukin-10 (IL-10) has anti-inflammatory and immunosuppressive effects. It is important for balancing the immune response and avoiding the steady state of immunological homeostasis from tipping into inflamm-aging and disease-inducing states. One of IL-10’s most essential physiological functions is to protect neurons from hypoxic and ischemic damage, glutamate-induced excitotoxicity and neuronal death.
Inflammatory indicators in the blood, such as IL-6, IL-10, and TNFα, may be used to identify those who are at high risk of poor cognitive outcomes.
The aim of the present study was to study the possible association between the serum level of interleukin 10 (IL-10) and mild cognitive impairment in elderly population.
This cross-sectional study included 90 elderly persons aged 65 years and older (45 subjects with MCI & 45 subjects without MCI), All selected cases and control were subjected to history taking, full physical examination, Cognitive functions assessment using the Mini Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA) score and laboratory investigations including : CBC, ESR, CRP, ALT, AST, Serum protein, albumin, total bilirubin, blood urea, serum creatinine, complete urine analysis, Fastin