الفهرس 
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Abstract
Stroke is one of the leading causes of death and disability worldwide. Intracerebral hemorrhage, an important subtype of the stroke, is characterized by high mortality and morbidity rates.
Compared with ischemic stroke, hemorrhagic stroke is associated with higher mortality rate and currently there is no curative treatment.
Therefore, identification of modifiable risk factors to detect persons who are at increased risk of ICH, is highly important.
The risk factors for ICH are multiple either Modifiable as hypertension, increased alcohol intake, decreased LDL, decreased TGs, medications and smoking or non-modifiable risk factors as Cerebral amyloid angiopathy.
Low levels of serum lipids have been suggested as a possible risk factor for intracerebral hemorrhage in many previous studies.
The exact mechanisms are still uncertain but there are many theories that can explain the relation between lipids levels and development of ICH;
Cholesterol and triglycerides play important structural roles in cell membranes. There is increased erythrocyte fragility with reduced levels of cholesterol. It has been proposed that lower cholesterol results in a weakened endothelium (weakened endothelium may be more susceptible to microaneurysms, the chief pathological finding of cerebral hemorrhages) that may lead to arterial fragility, hemorrhage and also slower repair after small hemorrhages.
Our Study aimed to describe the lipid abnormality and its association with clinical characteristics of intracerebral hemorrhage
The patients were selected from inpatients in neurology department at Ain Shams University Hospitals in the period from October 2020 to September 2021.
The study included one hundred patients more than eighteen years old with primary spontaneous non traumatic intracerebral haemorrhage, documented by CT brain within 24 hours of symptoms onset.
All patients included in the study were subjected to detailed medical history and examination with detailed neurological examination including assessment of GCS, NIHSS and Intracerebral hemorrhage score.
Also, all patients were subjected to total lipid profile investigation following 12 hours fasting and within 24 hours of admission.
Random blood sugar, complete blood picture, coagulation profile, renal and liver function tests were also performed.
Computed tomographic scan of the brain was performed with the objective of obtaining information regarding ICH as the site, volume, shape of haemorrhage and the presence of intraventricular extension. Also, follow up CT brain performed, one week after the onset, to assess hematoma expansion and its relation to lipid profile.
We found 67% of ICH patients with TGs (<150 mg/dl), 52% with TC (<200mg/dl), 53% with LDL (<100mg/dl), and 67% with VLDL levels (<30mg/dl). We found a significant association between TGs, TC, LDL and VLDL levels and incidence of ICH, unlike HDL.
There were nine patients (9%) died during the follow up, while eighteen patients (18%) were complicated with hematoma expansion. We found no relation between lipid profile and outcome of ICH as regard hematoma expansion and mortality rates.