الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
This study was carried out in the Department of Clinical Pathology, Assiut University Hospital, on 474 individuals, selected from the obstetric outpatient clinic and health care workers in Woman Health Hospital in Assiut University Hospital during the period from January 2017 to December 2020. They were pregnant women in the third trimester. Their age ranged between 20 and 45 years old. They were classified into two groups: group I: 247 patients, their ages were ≤ 28 years old (born in 1992 and after) who were supposed to have received hepatitis B vaccination in their scheduled vaccinations according to the Egyptian vaccination schedule. group II: 227 patients, their ages were ˃ 28 years old (born before 1992) who did not receive hepatitis B vaccination in their scheduled vaccinations. All participants were subjected to the following: • History• Routine investigations (Maternal blood samples) Liver function test: Total protein, Albumin, ALT, AST and ALP, Total bilirubin and Direct bilirubin Serological marker of HBV. • Specific investigations (Maternal and fetal blood samples): Detection of HBV DNA (Viral load) by real time PCR. In this study, there was a statistically significant increase in the total number of deliveries, total number of vaginal deliveries, total number of CS deliveries, and total number of living children in unvaccinated cases in comparison to vaccinated cases. There was no statistically significant difference in the levels of ALT, AST, ALP, total protein, albumin, total billirubin, and direct billirubin between the two groups. There was no statistically significant difference in the number of positive and negative cases of HBs Ab between the two groups, but there was a statistically significant increase in HBsAb level in the unvaccinated group when compared to the vaccinated group. There was a statistically significant increase in the number of HBc Ab total positive cases in the unvaccinated group when compared to the vaccinated group. There was no statistically significant difference in the number of positive and negative cases of HBc Ab and/or HBs Ab between the two groups, and all the studied cases in both groups were negative for HBc IgM. There was no statistically significant difference in the number of positive and negative cases of HBV- PCR between the two mother groups, and PCR testing for babies (cord blood samples) of both study groups was negative in all cases. There was no correlation between the level of liver enzymes and the number of HBcAb or HBsAb positive cases, nor between the level of liver enzymes and the level of HBsAb in our study patients. There was a positive correlation between the number of total deliveries and the positivity of HBcAb. There was also a positive correlation between the number of CS deliveries and the positivity of HBc Ab in the patents of this study. In the studied cases, there was no correlation between the number of total, vaginal, and CS deliveries and HBs Ab positive cases. There was a positive correlation between the number of VD and HBs Ab level and a positive correlation between the total number of deliveries and HBs Ab level, but there was no correlation between the number of CS deliveries and HBs Ab level.