الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 148 |  |  |
| | | from | 148 | | |
Abstract
Cutaneous T-cell lymphomas (CTCLs) are a heterogenous group of extranodal non-Hodgkin’s lymphomas primarily targeting the skin and may progress to involve extracutaneous sites (1). Mycosis fungoides (MF) is the most common type of CTCLs; MF is characterized by monoclonal proliferation of skin-homing, neoplastic CD4+ T- lymphocytes. Mycosis fungoides is presented clinically with early patches and plaques which may progress later into tumors (2). Diagnosis of MF particularly; its early stage has been a difficult challenge to dermatologists because of the presence of multiple clinical and histopathological variants to MF (3). Moreover, there is clinical and histopathological similarity between MF and various benign inflammatory dermatosis such as parapsoriasis, psoriasis, and chronic eczema. Therefore, clinico-pathological correlation is of a great value in diagnosis of MF (4). Increased CD4: CD8 ratio (normal value is 2: 1) mostly favors diagnosis of MF. However, there are unusual variants of MF characterized by decreased CD4:CD8 ratio such as the hypopigmented variant (5). Molecular biology has added more accuracy to the diagnosis of MF, with multiple molecular markers which have been emerged recently to confirm the diagnosis of MF with promising therapeutic targets (6).