الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Necrotizing enterocolitis is devastating disease that affects mostly the gastrointestinal tract of premature neonates results in inflammation and bacterial invasion of the bowel wall. NEC is characterized by gastrointestinal and systemic signs and symptoms including feeding intolerance, delayed gastric emptying, abdominal distention or tenderness, occult or gross blood in the stool, lethargy, apnea, respiratory distress, and poor perfusion. There has been increasing recognition that genetic factors modulate susceptibility or severity of NEC. The aim of this study was to study the relationship between Retinoic acid receptor responder protein 2 gene polymorphism and susceptibility to necrotizing enterocolitis in neonates to help in its early prediction. This prospective case-control study was conducted in the department of Pediatrics, Faculty of Medicine, Menoufia University in collaboration with the Molecular Biology and Medical Biochemistry Department from October 2020 till October 2021 with approval number (9119327) at 23/10/2019. This study included 140 neonates divided into two groups: group (1): Includes 70 newborns (52 male, 18 female) diagnosed with proven and complicated necrotizing enterocolitis according to Bell’s staging (51) fulfilling all inclusion and exclusion criteria. group II (control group): Include 70 healthy newborns (47 male, 23 female) as a control group.