الفهرس 
Aim of the studyOnly 14 pages are availabe for public view
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Abstract
Neonatal necrotizing enterocolitis is a severe intestinal disease that occurs predominantly in preterm infants and is one of the leading causes of morbidity and mortality in neonatal intensive care units. It is a disorder characterized by the ischemic necrosis of the intestinal mucosa, inflammation, invasion of gas-formation organisms and diffusion of gas in the muscular and portal venous systems.
New studies suggested that there is genetic predisposition for NEC.
Interestingly, nicotinamide phosphoribosyl transferase (NAMPT) (visfatin) is known to be an adipocytokine, it is an important mediator of inflammation that induces production of inflammatory cytokines after exposure to oxidative stress which could leads to cellular injury and production of free radicals that promotes an increased risk of FR-related diseases as necrotizing enterocolitis, hypoxic-ischemic encephalopathy, intraventricular hemorrhage, bronchopulmonary dysplasia and retinopathy of prematurity.
So, we aimed in the present study to investigate visfatin gene polymorphisms (rs3801266 and rs4730153) and the susceptibility to necrotizing enterocolitis in neonates to help in its early prediction.
This prospective case-control study recruited cases diagnosed with NEC from NICUs of Menoufia, Behaira and Fayoum governments in the period from October 2020 till October 2021 after approval of ethical committee (9119311) at (23/10/2019); included 140 newborns that were divided as:
group 1 (cases): Includes 70 newborns (52 males, 18 females) diagnosed with proven and complicated necrotizing enterocolitis according to Bell’s staging (5) fulfilling all inclusion and exclusion criteria.
group 2 (controls): Include 70 healthy newborns (47 males,