الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Despite advances in early detection, breast cancer remains the second most frequent cause of cancer mortality in women. It is the most common invasive and metastatic malignancy of breast tumors that confound treatment. Novel agents or treatments are urgently needed to improve the outcome for the large number of patients who relapse after receiving the currently available breast cancer therapies, since the existing therapies are no longer effective in these patients. Preceding reports expose that cancer cells require high amount of amino acids to support their fast proliferation rate. It was found that enzymes targeting those amino acids essential for the proliferation of cancerous cells are one of the tools used in cancer therapy now a day. In the present study, the arginase and pegylated arginase were examined their effects on MNU induced mammary tumor of experimental animal. and were investigated for their roles on apoptotic signals such as P53, p21 ,Bax, STAT3, β-catenin and cyclin D.