الفهرس 
Evaluation of the therapeutic effects of proton pump inhibitorsand Spirulina Platensis on non-alcoholic fatty liver disease in rats
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Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver damage, and it affects about 24% of the population worldwide.This study aimed to investigate the effect of omeprazole and spirulina platensis on hepatic and serum biochemical alterations in NAFLD induced by high-fat diet (HFD). Methods: 40 Male Wistar rats were divided into 4 groups; one served as a normal control.The other groups received HFD and subdivided into 3 subgroups; one was left untreated; the other 2 groups were treated orally with omeprazole (10 mg/kg) and spirulina (1000 mg/kg) for 30 consecutive days. Results: Omeprazole successfully decreased elevated serum pentraxin-3 (PTX-3) and cytokeratin-18 (CK-18) levels and hepatic sterol regulatory element binding protein-1c (SREBP-1c) expression, while spirulina had better impact on improving liver function enzymes, lipid profile and nuclear factor erythroid 2{u2013}related factor 2 (Nrf-2) levels compared to omeprazole. Both treatments had similar effects on normalizing glucose homeostasis, decreasing insulin resistance and improving adipocytokines levels.Conclusion: Effects of omeprazole and spirulina on markers of NAFLD appeared to be mediated by regulation of inflammatory, apoptotic and oxidative mediators.Thus, omeprazole and spirulina may find use as promising adjuvant therapy to ameliorate NAFLD