الفهرس 
Title : Biophysical studies on the effect of magnetic field on magnetoliposomes encapsulated with drug
ContantsOnly 14 pages are availabe for public view
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Abstract
Many people are dying from the effect of the drug rather than the disease; that is why the application of the drug has been always a compromise. In the search for effective curing through combining accurate and invasive techniques; aiming to increase the rate of targeted drug release invasively, we designed Magneto-Liposomes (MLs) loaded with Erythromycin drug and subjected it to 5 and 15mT alternating magnetic fields (AMF) at 100 kHz for 30 minutes of exposure.Percentage of Erythromycin released was tested using UPLC-MS/MS method for every hour after exposure until 8 hours, then at 24 hours post-exposure. During exposure, the temperature of the sample was recorded using an IR thermometer.Results showed an elevated temperature of 4 C in the case of exposure to 5mT and of 24 C in the case of exposure to 15mT. In addition, an increase in the percentage of drug release in comparison with the control group.Significantly, upon increasing the intensity of the AMF, the release rate was increased. Exposing Erythromycin-encapsulated ML to AMF accelerated the release rate due to the mechanical actuation of the nanoparticles