الفهرس 
Epicardial fat, impact on cardiovascular risk factors and relation to atherosclerosis
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Abstract
Objectives:To evaluate the association between epicardial fat volume and other cardiovascular risk factors and to evaluate the relation between epicardial fat volume and atherosclerotic coronary artery disease. background: Epicardial adipose tissue is not a simple lipid storage unit; it serves as an endocrine and paracrine organ, having a role in maintaining the homeostasis of body energy and metabolism, and a major source of anti-inflammatory and pro-inflammatory adipokines, which have significant impact on cardiac function and morphology. Epicardial adipose tissue can locally affect the coronary arteries and play a significant role in the development and progression of coronary artery disease (CAD). EAT quantification may be relatively easily done by different imaging techniques. TTE is the most accessible. Cardiac magnetic resonance (CMR) is currently considered the gold standard for EAT quantification. Both thickness and volume can be easily measured by CMR methods:Thisprospectiveobservationalstudywasappliedonpatientswhohadbeenreferred for CMR in a private lab, performed from July 2019 till April 2021.The study included 60 patients. According to the results of previous angiograms and coronary MRA, Patients were categorized into two main groups: group I (Absent coronary artery disease group), group II (Present coronary artery disease group). The two groups were assessed for: The clinical presentations and the risk factors (age, sex, smoking, dyslipidemia, hypertension, diabetes, and obesity). Relations between epicardial fat volume (EFV) and cardiovascular risk factors. Relations between EFV and presence or absence of CAD, between EFV and the segmental distribution of the obstructive lesions in the coronary tree in group II, between EFV and the number of the affected vessels in group II. ROC curve analysis performed to detect best cutoff value of epicardial fat volume for detection of obstructiveCAD. Results:The study included 60 patients, There were 49 males (81.7%) and 11 females (18.3%), with a mean age of 48.6 ± 11.9 years. group I included 19 males (76 %) and 6 females (24 %), with a mean age of 38.2 ± 7.3 years. group II included 30 males (85.7 %) and 5 females (14.3 %) with a mean age of 56.1 ± 8.4 years. EFV was found to have a statistically significant correlation to age (P < 0.001), Smoking (P = 0.013), hypertension (P = 0.021), diabetes (P < 0.001), dyslipidemia (P < 0.001), Obesity (P < 0.001) and BMI (P < .001) in the whole study population