الفهرس 
Drug-drug interaction in hospitalized children with liver disease
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Abstract
Background: Drug drug interaction (DDI) concept refers to the possibility a drug can alter the effects of another when both are simultaneously administered. Within hospitals, the problem of DDIs may deserve extra attention. Patients with hepatic dysfunction may be more sensitive to the effects of several drugs as the liver plays a central role in drug pharmacokinetics. Aim of work: To assess frequency of DDI among inpatient children with liver diseases and classify the severity of DDI. Methods: The study included all inpatient children with liver disease who were admitted in the Pediatric Hepatology Unit during the time period from 1/12/2019 to 31/3/2020. DDI of all administrated drugs were assessed using two DDI screening programs (Lexicomp and Medscape Interaction Checker). Results: The study included 50 patients. Most of the patients had cholestatic disorders of infancy (76%). Cholangitis was the most common indication of admission. Twenty patients (40%) had DDI. The total number of DDI for all patients was 52. Mild DDI represented 34.5%, moderate DDI represented 54% and severe DDI 11.5 %. Number of DDI per patient ranged between 1-12. The most commonly used drugs were fat-soluble vitamins while the most common drugs that had DDI were fluconazole and cortisone (6 DDIs for each). The most common action needed was just monitoring. Interactions between fluconazole and other drugs need monitoring for QT prolongation