الفهرس 
Title : Transcranial Direct Current Stimulation Effect on Demented Patients
AbstractOnly 14 pages are availabe for public view
 |  | from | 210 |  |  |
| | | from | 210 | | |
Abstract
Background: Elderly individuals with dementia are commonly presented with impaired spatial navigation function, as a consequence of cognitive dysfunction, and declined mobility that all influence their participation in life. Transcranial direct current stimulation (tDCS) is a safe, non-invasive, promising treatment intervention for improving cognitive changes in dementia. Objective: To investigate the effectiveness of tDCS on improving spatial navigation and mobility in patients with dementia. Methods: A double-blinded, randomized, sham-controlled trial was conducted. Twenty-nine demented patients participated and were randomly divided into two; intervention (n=16; mean age 62.98 ±10.11 years) and sham (n=13, mean age 60.23±7.57 years) groups. The patients in the intervention group received active tDCS for 20 minutes by applying an intensity of (2 mA). The patients in the sham group received a sham tDCS for 20 minutes as well; however, the current was ramped up to 1 mA and remained constant for 30 seconds before ramping down. The primary outcomes measures included the timed and error measures of the Floor Maze test (FMT), Timed Up and GO test (TUG), and the10 Meter Walk Test (10 MWT). All measures were recorded pre- and post-stimulation for all patients, and the adverse effects were also measured. Results: Post-stimulation, performance on the FMT was significantly improved in the intervention group. Furthermore, a statistically significant change in both of the TUG and 10-MWT (p<0.05) was detected only in the intervention group. No serious adverse effects were reported in either group. Conclusion: The transcranial direct current stimulation can enhance both spatial navigation and mobility in demented patients