الفهرس 
Relation between serum albumin level and abnormal QTc interval in patients with ischemic heart disease and chronic kidney disease
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Abstract
Background: QT interval prolongation is found to be remarked in advanced chronic kidney disease patients, and with the inflammatory characteristics of low serum albumin and its relationship with cardiovascular disease, our hypothesis that serum albumin may be a surrogate marker independently associated with QTc interval prolongation in humans. Aim: To investigate if low serum albumin level is associated with prolongation of QT interval for early detection of malignant arrhythmia in patient with ischemic heart disease and chronic kidney disease. Methodology: The present study was conducted on 400 patients all are ischemic heart disease with chronic kidney disease. All patients were subjected to: thorough history taking, full clinical examination, surface ECG and laboratory investigation including serum albumin level and renal function tests. Result: Mean of serum albumin level in study group 3.65 ± 0.54, abnormal (<3.5 gm) low serum albumin observed in 144 patients (36% of study group) and normal serum albumin (>3.5 gm) in 256 patients (64% of study group). Mean of QTc interval in study group 445.68 ± 45.31, mean of corrected QT interval in patients with normal serum albumin level 431.5 ± 32.73 and with patients with abnormal serum albumin 470.88 ± 53.11. Conclusion: The present study indicates that prolongation of QTc interval in patients with ischemic heart disease and chronic kidney disease is associated with low serum albumin level