الفهرس 
Anaplastic thyroid carcinoma; 10 years single institutional experience
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Abstract
In the current study, we report our experience with anaplastic thyroid carcinoma , and include a summary of the current literature to provide a reference for the management of this disease. We collected and analyzed retrospective data on the pathology, management, of patients with anaplastic thyroid carcinoma who underwent surgical management at department of surgical oncology, National Cancer Institute, Cairo University (NCI) from (January 2008 - January 2018). Anaplastic thyroid carcinoma is a rare disease, in our study 55 patients in 10 years from 2008 to 2018 were identified. There were 14 males(25.5%) and 41 females (74.5%) with the median age at presentation 65 years. Most of patients were diagnosed at stage T4c at presentation (41.8%). FNAC was the diagnostic biopsy in 60% of patients. 52.7% of patients were presented with gross extra-thyroid extension clinically or radiologically Surgical intervention was done in 45 patients . Palliative surgery was done in 27 patients of them. Surgical resection margins were identified in 26 patients . Surgical margins were free in 17 patients (65.4%). Most of patients(90.9%) had marked mitosis regarding histopathology. The median follow-up was 5 months. Wide spread lung metastasis was the main cause of death (52.2%). On uni-variant analysis, we found that age more than 65 years, absence of gross extra-thyroid extension, R0 resection, lymph node resection, adjuvant RTH and absence of recurrence to be statistically significant predictors of improved survival. However, on multivariate significant predictors of improved outcome