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العنوان
Modulation of chemotherapeutic induced resistance in hepatocellular carcinoma cell lines /
الناشر
Hebatullah Effat Abdelaziz Elewa ,
المؤلف
Hebatullah Effat Abdelaziz Elewa
هيئة الاعداد
باحث / Hebatullah Effat Abdelaziz Elewa
مشرف / Motawa Essa Elhusseiny
مشرف / Sabry K. Shaarawy
مشرف / Abdel-Hady A. Abdelwahab
تاريخ النشر
2021
عدد الصفحات
176 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الأورام
تاريخ الإجازة
8/8/2021
مكان الإجازة
جامعة القاهرة - معهد الأورام القومى - Cancer Biology
الفهرس
Only 14 pages are availabe for public view

from 206

from 206

Abstract

IIntroduction: Hepatocellular carcinoma (HCC) represents the sixth common cancer and the third leading cause of cancer-related mortality worldwide. It is more prevalent in males than in females. In Egypt, HCC constitutes a noteworthy widespread health problem, as it is accountable for 27.3% and 14.3% of all cancers in males and females respectively.The treatment options for HCC are limited and rely on patient stage. Doxorubicin drug-eluting bead transcatheter chemoembolization (TACE), a standard of care for patients particularly in the middle or advanced stage HCC is one of the vitally important approach and more promising evolutions in HCC treatment and used to diminish tumor load. Doxorubicin (Dox) is one of the most advantageous agents frequently used drugs in TACE, it has been shown that Dox can persue drug resistance resulting in poor patient prognosis and survival. MicroRNAs (MiRNAs), characterized as short, non-coding RNAs consisting of 18{u2013}25 nucleotides, were mentioned as powerful regulators of target mRNAs and make fine-scale adjustments to protein outputs. MiRNAs have been a recent focus in attempts to understand the mechanisms of Abstract 2 chemotherapy resistance particularly examining their ability to modulate known mechanisms of resistance