الفهرس | Only 14 pages are availabe for public view |
Abstract The present study is interested in testing structural properties, and preparation of binary blend with different surfactant solutions such as (Glycerin, Honey, and Tween (80)) and binary blend with specific surfactant (Tween (80)) and dropped Linezolid drug with different amounts (20, 40, 60 and 80mg/g). X-ray diffraction (XRD) verified information about the nature (crystal/amorphous) lattice arrangement which appeared for binary blend after adding suitable values of surfactants displayed that the surfactants dispersed in the blend matrix. While Linezolid was incorporated into the polymer blend/Tween (80) do not hinder crystal peaks of Linezolid drug due to the Linezolid drug represented (II) form. Fourier transform infrared spectroscopy (FTIR) verified information about the functional groups that distinguished the samples which appeared for binary blend after adding suitable values of surfactants and clarified the interaction and complexation between the Na-CMC/Na-Alg polymer matrix functional groups and surfactants while the spectrum of blend/Tween (80) revealed the effective incorporation of the Linezolid drug due to chemical interaction between blend/Tween (80) and drug. Ultraviolet and visible analysis (UV/Vis.) and optical studies appeared effectively regulate the optical properties of the binary blend. While the reaction between blend/surfactant and Linezolid showed a wide band and disappearance of =CO stretching at (1735 cm−1) in Tween (80) absorption bands due to the split and the building again of these bonds. Scanning electron microscopy (SEM) verified that the surface roughness may result from the larger space between the blend and different surfactants which is beneficial for cell growth and may therefore benefit wound healing. Antibacterial activity is assigned to the large surface area which enriches the plain invasion of the drug inside the tested microbes and fungus walls. |