الفهرس 
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Abstract
This work was conducted to investigate comparative hepatoprotective
effect of Phyllanthus niruri (PN) and Plantago major (PM) against
toxicity with carbon tetrachloride (CCl4) in rats. Sixty rats were equally
distributed into six groups. The first group received purified water and was
kept as a control. The second and third groups were given oral PN and PM
(500 mg/kg/day) for 31 days, respectively. The fourth group was injected
CCl4 (2 ml/kg/day) intraperitoneally on 15th and 16th day of the
experiment. The fifth and sixth groups received orally PN and PM (500
mg/kg/day) respectively for 31 days and injected CCl4 on 15th and 16th
day. On day 17 and day 32 of the trial, blood samples were collected for
biochemical analysis, and liver specimens were gathered for estimation of
MDA, antioxidants, apoptotic markers, interleukins and histopathological
changes. Our results revealed a significant increase in ALT, AST, ALP,
GGT, total bilirubin, direct and indirect bilirubin and lipid profile and a
significant decline in total protein and albumin in CCl4 group. Also,
biomarkers measured in tissue revealed a significant increase in MDA,
active caspase-3, p53, TNF-α, IL-1β, IL-18 & IL-10 and a significant
decline in GSH and SOD in CCl4 group. However, intoxicated groups
treated with PN and PM showed marked improvement in the measured
parameters. It could be concluded that PN and PM have hepatoprotective,
antioxidant and anti-inflammatory effects especially, PM which showed
better improvement than PN against CCl4 hepatotoxicity in rats.