الفهرس 
Introduction TheOnly 14 pages are availabe for public view
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Abstract
Nasal route has been explored widely for delivery of a large number of drug molecules, owing to its rich vasculature and thin epithelial lining due to which when a drug is administered via nasal route it directly reaches systemic circulation and provides rapid onset of action. Mucoadhesive nasal gels are the most prominent noninvasive dosage forms through which a drug can reach systemic circulation directly without undergoing first pass effect and this enhances underlying bioavailability of the drug.
The aim of study; to assess if the mucoadhesive gel can be considered as a suitable vehicle for drug delivery intranasally in an animal model using rabbits.
Methods; in this experimental study we had three groups Group1(13): non-diseased, received intranasal Neomycin-loaded mucoadhesive gel as a thin film of 0.5% gel twice daily for 10 days, Group2 (13): non-diseased, receives intranasal topical ciprofloxacin on mucoadhesive gel as 0.3% gel twice daily for 10 days. And group 3 (10): Non-diseased, Control, receives no treatment.
After animal sacrificed the nasal mucosa was harvested in all groups for scanning electron microscopic study.
Results; The current study, does not show any significant alteration of the mucosa after both drugs application in compare to control group, as we found in neomycin group few changes as; only 7.7% of cases have dendritic nuclei, regarding organelles 15.4% of cases have rich organelles, 7.7% of cases have few organelles and 30.8% have variable organelles. Only 7.7% of cases are mostly deciliated, but different cells were found as; Goblet cell in 38.5%, apoptic cells in 30.8%, Congestion in 46.1%.