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Abstract Burn injury is a serious pathology, potentially leading to severe morbidity and significant mortality (1). It is a leading cause of unintentional death and injury in children, with the majority being minor (less than 10%). However, a significant number of children sustain burns greater than 15% total body surface area(TBSA), leading to the initiation of the systemic inflammatory response syndrome (2). An estimated 6 million patients seek medical help for burns annually, but the majority are treated in outpatient clinics. The need to treatment in a specialized burn unit depends on the severity of the burn, the concomitant trauma, and the general condition of the patient (1). Evaluating the risk of death in burn patients is essential for their overall treatment, selecting and improving management regimens in the future (3). Critical illness from thermal injury causes profound changes in the immune system and in particular cellular immune responsiveness. This is characterized by an initial pro_inflammatory phase termed the systemic inflammatory response syndrome (SIRS), which involves a large systemic release of cytokines and is defined by at least two of the following four criteria: fever, tachycardia, tachypnea, and leukocytosis or leukopenia (4). |