الفهرس 
Hotair (homeobox antisense intergenic rna) and gas-5 (growth arrest{u2013}specific 5) expressions as biomarkers for early diagnosis of multiple sclerosis (MS)
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Abstract
Aims: Long non-coding RNAs (lncRNAs) were believed to play a role in the pathogenesis of many neurological disorders. We investigated the expression of two lncRNAs; HOTAIR and GAS-5 in patients with multiple sclerosis (MS) to clarify their role in MS pathogenesis and their impact on clinical course of the disease. Methods: This case-control study was conducted on 134 subjects; 74 patients with MS fulfilling the revised McDonald criteria and 60 healthy age- and sex- matched control. The clinical disability was evaluated using the expanded disability status scale (EDSS). lncRNAs expression was performed using Quantitative RT-PCR for the two lncRNAs; HOTAIR and GAS-5. Results: HOTAIR was found to be significantly down-regulated in MS patients (p< 0.001). GAS-5 was found to be significantly up-regulated in MS patients (p=0.002). GAS-5 expression was significantly higher in male patients than female patients (p=0.049), patients who initially represented with weakness had significantly higher expression levels of GAS-5 as compared to patients with ataxia (p=0.008)